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July 30

Animals in Space

Animals in Space

In 1957, a Soviet dog named Laika became the first living creature to orbit the Earth.

The First
In 1957, a Soviet dog named Laika became the first living creature to orbit the Earth. Originally a stray, Laika was selected over two other trainees. Though she died a few hours after launch, her trip proved that a living passenger could survive being launched into orbit and endure weightlessness.

Handlers at the Soviet Academy of Sciences show off some of the dogs in their space program.

Space Dogs
Handlers at the Soviet Academy of Sciences show off some of the dogs in their space program. During the 1950s and 1960s, the Russians launched missions that included passenger slots for at least 57 dogs. The number of animals that actually reached space is smaller, as several dogs went more than once.

A squirrel monkey, his body swathed in protective silicon rubber padding, is strapped into a capsule as part of a training exercise for spaceflight.

Little Guy
A squirrel monkey, his body swathed in protective silicon rubber padding, is strapped into a capsule as part of a training exercise for spaceflight. A comrade of his known as Gordo was similarly secured for a 1958 fifteen-minute flight that ascended to a height of 310 miles. Though it is believed that Gordo survived the entirety of his flight, the parachute on his craft failed to open and he and his capsule were lost at sea.

The first two monkeys to survive their trip into space are presented at a NASA press conference in 1959.

Able and Baker
The first two monkeys to survive their trip into space are presented at a NASA press conference in 1959. Able, on the left, a seven-pound rhesus monkey, and Baker, an 11-ounce squirrel monkey from Peru, withstood forces 38 times the normal pull of gravity and endured weightlessness for about 9 minutes during their historic flight. Able died four days after returning to earth during a relatively simple surgery to remove an infected electrode. Baker lived until 1984.

In early 1961, just a few months before Soviet cosmonaut Yuri Gagarin launched into orbit, NASA was using chimps to help iron out the kinks in its Mercury program.

Chimp in Training
In early 1961, just a few months before Soviet cosmonaut Yuri Gagarin launched into orbit, NASA was using chimps to help iron out the kinks in its Mercury program. Approximately 20 of them were trained at Holloman Air Force Base in New Mexico on equipment simulating space flight, like the rocket sled, above.

The chimps in the Holloman training program were taught how to do simple tasks in response to electric lights and sounds.

Timed Task
The chimps in the Holloman training program were taught how to do simple tasks in response to electric lights and sounds. Jim, the chimp whose efforts are photographed here, has made a mistake: the experiment calls for him to hit the odd shape, in this case, the circle in the middle.

The chimps in the Holloman program were prepared for launch in a Mercury capsule, similar to the one above.

Capsule Position
The chimps in the Holloman program were prepared for launch in a Mercury capsule, similar to the one above.

Two chimps from the Holloman program were successfully launched into orbit.

In Space
Two chimps from the Holloman program were successfully launched into orbit. A chimp named Ham, whose journey lasted 16 minutes and 59 seconds, took off in January 1961. His comrade, Enos, blasted off ten months later, above, for a journey that circled the Earth two times.

After his brief journey into orbit, Ham splashed down in the Atlantic Ocean and he and his capsule were recovered by a rescue ship. He only suffered a bruised nose during his flight.

Safe Return
After his brief journey into orbit, Ham splashed down in the Atlantic Ocean and he and his capsule were recovered by a rescue ship. He only suffered a bruised nose during his flight.

Once Ham and Enos had completed their journeys, NASA felt ready to send a human into orbit. On February 20, 1962, John Glenn became the first American to circle the Earth.

Manned Space Flight
Once Ham and Enos had completed their journeys, NASA felt ready to send a human into orbit. On February 20, 1962, John Glenn became the first American to circle the Earth.

UN: Fewer AIDS Deaths Globally

UN: Fewer AIDS Deaths Globally

Tuesday, Jul. 29, 2008 By AP/MARIA CHENG
HIV UN AIDS
An HIV positive patient, sleeps in her room in the eastern Indian city of Kolkata , India
Parth Sanyal / REUTERS
(LONDON) — Fewer people are dying of AIDS, more patients are on HIV medication and the global AIDS epidemic is stable after peaking in the late 1990s.

But the United Nations AIDS agency warned in its yearly report Tuesday that governments will need to continue setting aside millions of dollars for AIDS in the coming decades as patients live longer on AIDS treatment.

"We've achieved more in the past five years than in the previous 20 years," said Peter Piot, the agency's executive director. "But if we relax now, it would be disastrous. It would wipe out all of our previous investments."

UNAIDS estimates the number of AIDS case worldwide at 33 million; its previous estimate of 40 million was revised last year because of changes to how it counts cases.

Countries in sub-Saharan Africa including South Africa, Botswana and Swaziland, remain the center of the AIDS epidemic. The region has about 67 percent of all people infected with HIV and 72 percent of all AIDS deaths.

Outside sub-Saharan Africa, AIDS mainly affects drug users, gay men and sex workers.

Officials estimate that 2 million people died from AIDS last year, down from approximately 2.2 million in 2005.

The most dramatic figures are in treatment: The number of people on AIDS medication jumped by 10 times in the last six years, with some 300,000 taking AIDS drugs in 2003 compared to about 3 million in 2007. AIDS drugs have become much cheaper and more available because of a variety of government and private programs.

But millions of others still do not have access to the drugs, and those who do will need to remain on them to stay alive.

Still, millions of new cases of HIV infection are reported every year, the agency said. HIV is rising in several countries beyond Africa, including China, Germany, Indonesia, Russia and Britain, according to the report, which was issued in advance of next week's international AIDS conference in Mexico City.

The good news is that the global number of new infections was down to about 2.7 million people in 2007 from a peak of about 5 million new cases annually in the early 2000s.

However, the report — based on government data from 147 countries — warned there could be future waves of infection. The agency said it would be difficult to predict whether the AIDS epidemic might spike again.

Experts said it's too early to stop worrying about AIDS.

"I'm not sure we will ever get to a point where we can say this is not a public health problem," said James Chin, a clinical professor of epidemiology at the University of California, Berkeley.

Last week, the U.S. government tripled the amount of money it will spend on AIDS and other diseases around the world to $48 billion over five years.

"The objective of AIDS programs is to provide access to medication to everyone who needs it," Chin said. "Until that's accomplished, this won't go away."

The slow decline of AIDS-related deaths is "dismally disappointing," said Selina Lo, medical coordinator for Medecins Sans Frontiere's Access to Essential Medicines campaign. The group also is known as Doctors Without Borders.

She called it evidence that strategies need to change.

Some experts said health officials know what to do — but still aren't doing things like spending more money on prevention.

"We just don't know how to get governments to do nice things for junkies, sex workers and gay boys," said Elizabeth Pisani, a former UNAIDS epidemiologist who wrote a book about the mistakes made in AIDS programs.

Children: Bacteria Linked to Lower Asthma Rates

Children: Bacteria Linked to Lower Asthma Rates
By BINA VENKATARAMAN
Published: July 29, 2008
Common bacteria that have lived in human stomachs for generations are associated with lower rates of childhood asthma, researchers are reporting.

Their study, to appear on Aug. 15 in The Journal of Infectious Diseases, does not prove that the microflora, Helicobacter pylori, actually help protect children from asthma. It may be that asthmatics do not host the bacteria for other reasons.

Still, the recent study, conducted by researchers at New York University School of Medicine and the Veterans Affairs Medical Center in New York, found that children who carried H. pylori were 40 percent less likely to have asthma before age 5. And children ages 3 to 13 who had the bacteria were 60 percent less likely to report that they had asthma at the time of the study. The study relied on interviews with individuals and their families to determine whether the children had asthma.

Antibiotics kill helpful bacteria as well as harmful ones, and previous research has linked antibiotic use in children with higher risk for asthma.

“H. pylori is disappearing, and this is a fact that probably cannot be changed,” said Dr. Yu Chen, the lead author of the study. “But it’s important to realize that bacteria that have been living with us for millions of years may actually have some beneficial qualities.”

Is There a Laziness Gene?

Is There a Laziness Gene?

Wednesday, Jul. 30, 2008 By DEIRDRE VAN DYK
White mouse running on wheel
Tetra Images / Corbis
Have you ever wondered why you can't get off the couch and exercise — despite paying for an expensive gym membership, despite your New Year's resolutions, even despite the doctor's scolding at your last check-up? Turns out that your inertia may be coded right into your genes.

Based on some intriguing, preliminary studies in animals, J. Timothy Lightfoot, a kinesiologist, and his team at University of North Carolina, Charlotte, suggest that genetics may indeed predispose some of us for sloth. Using mice specially bred and selected according to their activity levels, Lightfoot identified 20 different genomic locations that work in tandem to influence activity levels in mice — specifically, how far the animals will run. Lightfoot's team is the first to identify these genetic areas, and the first to figure out that they function in concert. The researchers say the areas they found on the mouse genome may have analogs in humans, and the UNC team is now gearing up to conduct a similar study in men and women. "We have put forward a fairly complete genomic map of the areas that are associated with regulation of physical activity," says Lightfoot, whose study is published in the current issue of the Journal of Heredity.

Lightfoot, who originally wanted to coach college basketball and is himself an avid athlete, began studying activity levels as a way to try to figure out why, given all we know about the overwhelming health benefits of physical activity, so many people still choose not to exercise. A lecture at Johns Hopkins about genetics and lung disease served as Lightfoot's eureka moment, and he became interested in studying genes as our prime mover. For the new study, Lightfoot and his team bred two strains of mice — active and inactive. Researchers then cross-bred two generations of the active and inactive mice, ending up with a study group of 310 genetically mixed offspring. At about 9 weeks old, each mouse was housed in an individual cage and given an exercise wheel. Researchers measured how far, how long and how fast the animals ran every day for three weeks, at the end of which the mice were genotyped.

Exercise-prone mice put in a good 5 to 8 miles per day (the equivalent of an average man running 40 to 50 miles a day), versus 0.3 mile per day for inactive mice. While the exercise wheels of the activity-prone mice would turn all night, some of the sedentary mice devised ingenious ways to avoid activity. One stuffed wood shavings around the wheel and turned it into a bed; one used it as an, ahem, toilet; and one climbed on top of her wheel only to get a better look at the overhead sensors tracking her movements.

Although the animals' activity levels could not be entirely attributed to genes, researchers calculated that heredity accounted for about 50% of the differences in activity. They also found that activity-promoting genes were dominant traits in 75% of the exercise-loving mice. (Researchers don't know yet how often the activity-inclined genotype would naturally occur; Lightfoot says he found a fairly continuous range of activity levels, from extremely active to very low active, in about 30 mice strains he tested.) "When we used to talk about activity, it was whether or not people decided to be active," says Lightfoot. "Now it's clear that there's an inherent drive as to whether one is active or not active."

Exactly how that drive plays out in the body is still a mystery. There are two theories, Lightfoot says: genes may affect either the way muscles work — perhaps causing them to use energy more efficiently and preventing fatigue — or some higher-order biochemical circuit in the brain, such as levels of the neurotransmitters dopamine or serotonin. Researchers have examined the muscle tissue of the mice in the study, however, and early data, which has not yet been published, suggests there's no difference in their function. So researchers' best guess is that the drive to exercise is at least partly influenced by brain chemicals — a reasonable hypothesis, given that dopamine or serotonin plays a significant role in several human drives and behaviors, including hunger, addiction, mood and movement disorders like Parkinson's disease.

Chemistry is not destiny, of course. Lightfoot hopes to use his research to help determine which patients may need a bigger boost to get moving — he thinks that perhaps close supervision by trainers or rewards for exercising will encourage genetic lazybones to get the gym. And maybe one day, he speculates, there might even be a drug to compensate for what your genes won't give you. A drug that makes you want to exercise? Now, that's a pill worth swallowing.

Could Metals Help Treat Cancer?

Could Metals Help Treat Cancer?

ScienceDaily (July 30, 2008) — A collaboration between chemists and biologists has made it possible to identify the effects of a new class of molecules, polyoxometalates (1), primarily composed of metals and oxygen. These molecules are very powerful inhibitors of a specific protein kinase, CK2, an enzyme that is overactive in a number of cancers. The enzyme's instrumental role in controlling cell proliferation and survival makes it an important target in the search for new medications.

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Structure of the protein kinase CK2 (left) and the structures of different polyoxometalate (POM) molecules (right). (Credit: Copyright B. Hasenknopf)

These results have just been published in the journal Chemistry and Biology by chemists from the Institut de chimie moléculaire (CNRS / UPMC) and biologists from the Institut de recherche en technologies et sciences pour le vivant (iRTSV, CEA de Grenoble / CNRS / Inserm.)

Phosphorylation enzymes (2) , which include the protein kinase CK2, play a critical role in controlling cell proliferation. Deregulated protein kinase activity is implicated in a number of cancers, which has led to a recent surge in research on molecules that can inhibit the activity of these enzymes. The currently known CK2 inhibitors are all organic compounds that neutralize enzymatic activity by binding to its active site (3).

The contribution of the study carried out by the researchers at the Institut de chimie moléculaire and the Institut de recherche en technologies et sciences pour le vivant was to reveal a new class of CK2 inhibitors. The new inhibitors are inorganic molecules, polyoxometalates (POMs), primarily made up of metals (molybdenum and tungsten) and oxygen. They are the most powerful CK2 inhibitors yet discovered, working at very low (nanomolar) concentrations. In addition, the researchers showed that the mode of action of POMs, although not yet fully understood, is completely new. Unlike organic inhibitors, POMs do not bind to the active site of the enzyme.

This work opens up several areas for further research: clarifying the mechanism of action of these new molecules, finding the minimum molecular entity that can inhibit enzyme activity, and finally, given its importance in the health field, improving knowledge of how the enzyme CK2 works. In the longer term, these results could pave the way for new approaches to developing anti-cancer drugs.

Notes:

(1) Polyoxometalates are anionic inorganic metal oxide structures that have valuable catalytic properties.

(2) Phosphorylation enzymes called protein kinases can attach a phosphate group to proteins that may be inactive enzymes. The addition of the phosphate group can activate these “silent” enzymes. Protein kinases thus play a central role in controlling the activity of numerous enzymes in the cell.

(3) The active site of an enzyme is a particular region where the substrates bind together and enzymatic reactions takes place.

Watching A 'New Star' Make The Universe Dusty

Watching A 'New Star' Make The Universe Dusty

ScienceDaily (July 27, 2008) — Using ESO's Very Large Telescope Interferometer, and its remarkable acuity, astronomers were able for the first time to witness the appearance of a shell of dusty gas around a star that had just erupted, and follow its evolution for more than 100 days.

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Artist's impression of the shell as deduced from the observations made in the mid-infrared (in the visible, it is almost opaque), using ESO's Very Large Telescope Interferometer.

This provides the astronomers with a new way to estimate the distance of this object and obtain invaluable information on the operating mode of stellar vampires, dense stars that suck material from a companion.

Although novae were first thought to be new stars appearing in the sky, hence their Latin name, they are now understood as signaling the brightening of a small, dense star. Novae occur in double star systems comprising a white dwarf - the end product of a solar-like star - and, generally, a low-mass normal star - a red dwarf. The two stars are so close together that the red dwarf cannot hold itself together and loses mass to its companion. Occasionally, the shell of matter that has fallen onto the ingesting star becomes unstable, leading to a thermonuclear explosion which makes the system brighter.

Nova Scorpii 2007a (or V1280 Scorpii), was discovered by Japanese amateur astronomers on 4 February 2007 towards the constellation Scorpius ("the Scorpion"). For a few days, it became brighter and brighter, reaching its maximum on 17 February, to become one of the brightest novae of the last 35 years. At that time, it was easily visible with the unaided eye.

Eleven days after reaching its maximum, astronomers witnessed the formation of dust around the object. Dust was present for more than 200 days, as the nova only slowly emerged from the smoke between October and November 2007. During these 200 days, the erupting source was screened out efficiently, becoming more than 10,000 times dimmer in the visual.

An unprecedented high spatial resolution monitoring of the dust formation event was carried out with the Very Large Telescope Interferometer (VLTI), extending over more than 5 months following the discovery. The astronomers first used the AMBER near-infrared instrument, then, as the nova continued to produce dust at a high rate, they moved to using the MIDI mid-infrared instrument, that is more sensitive to the radiation of the hot dust. Similarly, as the nova became fainter, the astronomers switched from the 1.8-m Auxiliary Telescopes to their larger brethren, the 8.2-m Unit Telescopes. With the interferometry mode, the resolution obtained is equivalent to using a telescope with a size between 35 and 71 metres (the distance between the 2 telescopes used).

The first observations, secured 23 days after the discovery, showed that the source was very compact, less than 1 thousandth of an arcsecond (1 milli-arcsecond or mas), which is a size comparable to viewing one grain of sand from about 100 kilometres away. A few days later, after the detection of the major dust formation event, the source measured 13 mas.

"It is most likely that the latter size corresponds to the diameter of the dust shell in expansion, while the size previously measured was an upper limit of the erupting source," explains lead author Olivier Chesneau. Over the following months the dusty shell expanded regularly, at a rate close to 2 million km/h.

"This is the first time that the dust shell of a nova is spatially resolved and its evolution traced starting from the onset of its formation up to the point that it becomes too diluted to be seen", says co-author Dipankar Banerjee, from India.

The measurement of the angular expansion rate, together with the knowledge of the expansion velocity, enables the astronomer to derive the distance of the object, in this case about 5500 light-years.

"This is a new and promising technique for providing distances of close novae. This was made possible because the state of the art facility of the VLTI, both in terms of infrastructure and management of the observations, allows one to schedule such observations," says co-author Markus Wittkowski from ESO.

Moreover, the quality of the data provided by the VLTI was such that it was possible to estimate the daily production of dust and infer the total mass ejected. "Overall, V1280 Sco probably ejected more than the equivalent of 33 times the mass of the Earth, a rather impressive feat if one considers that this mass was ejected from a star not larger in radius than the Earth," concludes Chesneau. Of this material, about a percent or less was in the form of dust.

In Beijing, Cash is Still King

In Beijing, Cash is Still King

If you look at Beijing’s soaring skyscrapers, gleaming motorways and glitzy shopping malls, it’s easy to conclude that this city is as modern as any in the world. And then the waiter brings the check. Sorry, madam, we don’t take credit cards.

In Beijing, more than any other big-country capital, cash is king. Official figures indicate that 110,000 Beijing businesses now accept credit cards, twice as many as in 2006. What those figures don’t show is how many accept only Chinese-issued cards (my guess is about half). And though 110,000 sounds like a large number, there are vastly more establishments that are extremely allergic to plastic of any color.

RMB

So when visiting Beijing, or some other Chinese city, it’s important to know how to get your hands on large amounts of cash. With an eye to the Olympics, Premier Wen Jiabao in 2006 ordered nine ministries and the central bank to “further develop consumer financial instruments.” The result was a vast expansion of retail banking – for decades virtually non-existent – including services for visitors. Though foreign credit cards may not yet be widely welcomed, foreign currency exchanges have proliferated, and it’s now possible to change cash and travelers checks at 80 percent of the city’s three-star-and-above hotels. Better yet, automated teller machines in Beijing are up to 9,400 and counting.

The trick is to find one that works. About half of all ATMs in China accept only credit and debit cards that are part of the domestic UnionPay system. So look for cash machines bearing the stickers of international networks like Visa, Plus, MasterCard and Cirrus. Then pray.

ATMs at Chinese banks get a workout – locals prefer them over the notoriously long lines at teller windows – so the machines are often out of cash or receipts or gas or spare parts. They also sometimes fail to make the connection to a foreigner’s bank. So if you get a message to contact your card issuer because your plastic has been declined, don’t despair. Just try another machine. And even when you find an ATM that works, withdrawals are typically limited to 2,000 yuan (about $280 at the current exchange rate) and sometimes less. Foreign banks like Citibank and HSBC have machines that dispense more. These are not numerous, but you will find a handful at the airport – both before and after customs.

Get as much cash as you can at one time, since you’ll be paying your bank’s $3 or $4 service fee no matter what amount you withdraw. Also, you’ll need those banknotes. Expect to pay for much of your food, transportation, tips, souvenirs, cheap sportswear at the Silk Market and, in some cases, even lodging in cash. Stacks of it. The largest bill is 100 yuan, worth only about $14 (it’s the red one, with Mao’s face on it). The government has put 36.5 billion new notes into circulation so far this year, twice as many as last year, so there is a good chance your stash of cash will be crisp and clean. Don’t be insulted if a cashier holds your bill up to the light to check its authenticity. Don’t be surprised if, upon handing over several bills, they are run through a counting machine, which nearly every Chinese business seems to have on hand. Or, more often, to be told that the credit card machine isn’t working right now, so how about paying in cash?

You can protest, stand on your rights as a credit-worthy customer of Visa, MasterCard or American Express, and ask to see the manager. That sometimes miraculously fixes the broken machine. But I always end up feeling like an idiot when I do the ugly American act. The alternative is to behave as the Chinese do: hand over a brick of bills and watch them be counted with the care found only in a country that loves its lucre, clean or filthy.

Diamonds May Have Been Life's Best Friend On Primordial Earth

Diamonds May Have Been Life's Best Friend On Primordial Earth

ScienceDaily (July 30, 2008) — Diamonds may have been life's best friend. Billions of years ago, the surface of these gems may have provided just the right conditions to foster the chemical reactions believed to have given rise to life on Earth, researchers in Germany report.

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Their study is scheduled for the August 6 issue of ACS' Crystal Growth & Design, a bi-monthly journal.

In the new study, Andrei Sommer, Dan Zhu, and Hans-Joerg Fecht point out that scientists have theorized for years that the chemical precursors of life gradually evolved from a so-called "primordial soup" of simpler molecules. But the details of how these simpler amino acids molecules, the building blocks of life, were assembled into complex polymers, remains one of science's long-standing mysteries.

To find out, the research team studied diamonds, crystallized forms of carbon which are older than the earliest forms of life on Earth. In a series of laboratory experiments, the scientists showed that after treatment with hydrogen, natural diamond forms crystalline layers of water on its surface, essential for the development of life, and involved in electrical conductivity. When primitive molecules landed on the surface of these hydrogenated diamonds in the atmosphere of early Earth, the resulting reaction may have been sufficient enough to generate more complex organic molecules that eventually gave rise to life, researchers say.

Scientists are reporting that diamonds could have created chemical reactions billions of years ago that were believed to have caused life on Earth. (Credit: Wikimedia Commons)

Climate Change: Secret Life Cycles Of Atmospheric Aerosols Can Be Illuminated With New Technology

Climate Change: Secret Life Cycles Of Atmospheric Aerosols Can Be Illuminated With New Technology

ScienceDaily (July 29, 2008) — An aerosol mass spectrometer developed by chemists from Aerodyne Research Inc. and Boston College is giving scientists who study airborne particles the technology they need to examine the life cycles of atmospheric aerosols – such as soot – and their impact on issues ranging from climate change to public health.

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Timothy B. Onasch, principal scientist for Aerodyne Research, Inc. (Billerica, Mass.) and Boston College chemistry professor Paul Davidovits check an apparatus they designed to produce uniform soot particles used for aerosols research. (Credit: Lee Pellegrini/Boston College)
 

BC Chemistry Professor Paul Davidovits and Aerodyne Principal Scientist Timothy B. Onasch say their novel spectrometer allows researchers to better understand what happens to these sub-microscopic particles that can absorb and scatter light and influence the lifetime of clouds.

"For scientists looking at climate change, the biggest uncertainty has to do with the effect of aerosol particles in the air," says Davidovits. "The issue is made that much more complex because aerosols can have different effects on climate. That means the target is constantly shifting."

The historic role of carbon-laden soot in climate change has been identified by researchers, particularly through ice samples taken from glaciers. Now scientists are focusing on tiny airborne particles of black carbon released into the atmosphere today in order to better understand the lifecycle of these aerosols in the atmosphere.

To that end, nearly 20 researchers from across the country brought other devices to the Davidovits lab this month to test and fine-tune these new tools developed by scientists from universities, industry and national laboratories at the forefront of this path-breaking science of the sky.

Hosted by Davidovits and Onasch, also an associate research professor at BC, the visiting researchers ran streams of laboratory-generated soot through devices able to analyze minute aerosol particles by mass, shape, chemical make-up, even the sound they make when warmed by light – a "pop" inaudible to the human ear.

"This is the cutting edge," says Dan Lack, a research scientist with the National Oceanic and Atmospheric Administration's Earth System Research Laboratory in Boulder, Colo. "Much of the technology in this room didn't exist until a few years ago. And there isn't another place in the country where you have all this technology running together in concert. It's a rare opportunity."

Among the 18 devices involved in the project are Billerica, MA-based Aerodyne's Aerosol Mass Spectrometer, Boulder-based Droplet Technologies' Single Particle Soot Photometer, and the NOAA-developed Cavity Ring-Down Aerosol Extinction and Photoacoustic Spectrometers, which shoot a laser beam into black carbon, causing the particle to "pop", emitting a frequency that's measured to gauge how much light carbon absorbs.

A technological focal point is a unique soot-particle generating apparatus operated by doctoral student Eben Cross, undergraduate Adam Ahern '09 and recent graduate Billy Wrobel '08. The design, construction, and operation of the device were funded by the atmospheric chemistry programs of the Department of Energy and the National Science Foundation.

In the race to determine the scope and speed of climate change and the influence of human activities on it, huge scientific efforts have focused on carbon dioxide gasses emitted largely from the burning of fossil fuels. Scientists believe particulates like black carbon may also contribute significantly to global warming.

For more than 15 years, Davidovits and his Aerodyne colleagues have pioneered the study of soot particles and gas-particle interactions, strengthening an understanding of the role of cloud and aerosol chemistry in acid rain, ozone depletion and climate change.

Aerosols raise temperatures, such as when black particles of soot rise in the sky, absorb sunlight and turn it into heat. Aerosols also can cool by reflecting light away from the earth. Clouds overstuffed with aerosols can inhibit rainfall.

While soot emitted from sources like diesel engines and electric power plants is a focus of study, not all aerosols are man-made. The deserts and arid landscapes of the world produce an estimated 10 to 20 billion tons of mineral aerosols a year. The air is full of biological aerosols as well – microbes, cells, and particles containing organic compounds.

Aerosols are somewhat fleeting. Unlike carbon dioxide, which can remain in the atmosphere for years, aerosols have an atmospheric life of about 10 to 20 days. In that time, they can absorb other molecules that alter their original state.

Measuring the many forms of atmospheric aerosols has led researchers to invent new devices, known as research-grade aerosol particle characterizing instruments, says Davidovits. The challenge now is to fine-tune those instruments in concert with each other in order to set reliable scientific benchmarks for future study.

Linked closely to the atmospheric effects of aerosols is a range of public health concerns, says Onasch.

"There is a need on many fronts – from the climate to public health – for greater understanding of the role aerosol particles play in our lives and what's happening here is the scientific community rising to meet those needs," says Onasch.

Did Dinosaur Soft Tissues Still Survive? New Research Challenges Notion

Did Dinosaur Soft Tissues Still Survive? New Research Challenges Notion

ScienceDaily (July 30, 2008) — Paleontologists in 2005 hailed research that apparently showed that soft, pliable tissues had been recovered from dissolved dinosaur bones, a major finding that would substantially widen the known range of preserved biomolecules.

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Arrows on this electron microscope image indicate biofilms, or slime, peeling away from the walls of vascular canals in dinosaur bone. (Credit: Thomas Kaye)
 

But new research challenges that finding and suggests that the supposed recovered dinosaur tissue is in reality biofilm – or slime.

"I believed that preserved soft tissues had been found, but I had to change my opinion," said Thomas Kaye, an associate researcher at the Burke Museum of Natural History and Culture at the University of Washington. "You have to go where the science leads, and the science leads me to believe that this is bacterial biofilm."

The original research, published in Science magazine, claimed the discovery of blood vessels and what appeared to be entire cells inside fossil bone of a Tyrannosaurus rex. The scientists had dissolved the bone in acid, leaving behind the blood vessel- and cell-like structures.

But in a paper published July 30 in PloS ONE, a journal of the open-access Public Library of Science, Kaye and his co-authors contend that what was really inside the T. rex bone was slimy biofilm created by bacteria that coated the voids once occupied by blood vessels and cells.

He likens the phenomenon to what would happen if you left a pail of rainwater sitting in your backyard. After a couple of weeks you would be able to feel the slime that had formed on the inner walls of the bucket.

"If you could dissolve the bucket away, you'd find soft, squishy material in the shape of the bucket, and that's the slime," Kaye said. "The same is true for dinosaur bones. If you dissolve away the bone, what's left is biofilm in the shape of vascular canals."

Co-authors of the new paper are Gary Gaugler of Microtechnics Inc. of Granite Bay, Calif., and Zbigniew Sawlowicz of Jagiellonian University in Poland.

Kaye said he began his research with the hope of being the second person to find preserved dinosaur tissues. In addition to the acid bath procedure used in the previous work, he added examination by electron microscope before the bones were dissolved. He was surprised by the findings.

The researchers found that what previously had been identified as remnants of blood cells, because of the presence of iron, were actually structures called framboids, microscopic mineral spheres bearing iron. They found similar spheres in a variety of other fossils from various time periods, including an extinct sea creature called an ammonite. In the ammonite they found the spheres in a place where the iron they contain could not have had any relationship to the presence of blood.

"We determined that these structures were too common to be exceptionally preserved tissue. We realized it couldn't be a one-time exceptional preservation," Kaye said.

The scientists also dissolved bone in acid, as had been done previously, and found the same soft tissue structures. They conducted a comparison using infrared mass spectroscopy and determined the structures were more closely related to modern biofilm than modern collagen, extracellular proteins associated with bone. Carbon dating placed the origin at around 1960.

Using an electron microscope, the researchers saw coatings on the vascular canal walls that contained gas bubbles, which they associated with the presence of methane-producing bacteria. In addition, they examined what looked like tiny cracks within the vascular canals and found that they were actually small troughs, or channels. Study at high magnification revealed the channels had rounded bottoms and bridged each other, indicating they were organically created, likely by bacteria moving in a very thick solution.

"From this evidence, we could determine that what had previously been reported as dinosaurian soft tissues were in fact biofilms, or slime," Kaye said.

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